The Gmail DSN 421-4.3.0 temporary system problem arises from a multitude of causes, broadly categorized as issues on Google's side, server-side problems, sender-side configurations, and network-related issues. Server-side problems encompass temporary server unavailability, overload, or maintenance. Sender-side issues include rate limiting, poor IP reputation, exceeding connection limits, incorrect SPF records, insufficient server resources, greylisting, shared IP limitations, throttling, and temporary TLS issues. Resolution strategies vary but often involve retrying the email, addressing SPF configuration, monitoring IP reputation, managing sending volume, ensuring sufficient server resources, and investigating potential greylisting or TLS issues.
14 marketer opinions
The Gmail DSN 421-4.3.0 temporary system problem is a transient issue that can arise from various causes, including temporary server issues, rate limiting, reputation problems, exceeding connection limits, incorrect SPF records, insufficient server resources, greylisting, shared IP limitations, and throttling by Google/Gmail. Resolution often involves retrying the email send later, ensuring proper authentication, monitoring sender reputation, correctly configuring SPF records, increasing server resources, and gradually sending emails to avoid throttling.
Marketer view
Email marketer from Email Geeks confirms that the issue could be due to continued sending to over-quota/out-of-storage mailboxes.
24 Dec 2023 - Email Geeks
Marketer view
Email marketer from StackExchange suggests that greylisting mechanisms often cause 421 errors as a deliberate measure to filter spam. These mechanisms defer delivery attempts from unknown senders, expecting legitimate mail servers to retry sending.
12 May 2025 - StackExchange
3 expert opinions
The Gmail DSN 421-4.3.0 temporary system problem is caused by a variety of factors, including greylisting, temporary server issues (overload, maintenance, network problems), and temporary TLS issues. Resolution typically involves retrying the message delivery after some time and addressing TLS configuration issues if present.
Expert view
Expert from Word to the Wise highlights that temporary TLS issues can result in 421 errors. Configuration issues can cause the encryption to fail temporarily.
7 Jul 2023 - Word to the Wise
Expert view
Expert from Spam Resource clarifies that the 421 status code indicates a temporary issue, such as server overload, maintenance, or network problems. Retrying the message delivery after some time is recommended.
5 Sep 2024 - Spam Resource
5 technical articles
The Gmail DSN 421-4.3.0 temporary system problem is a transient error indicating temporary issues on Google's side, with the remote host, or within the transport layer (DNS, network timeouts). Documentation advises retrying the connection later as the primary course of action. The error generally resolves itself, and further action is not typically required.
Technical article
Documentation from Microsoft Learn indicates a 421 SMTP response code generally indicates that the service is not available and the connection will be closed. The application should retry.
22 Feb 2023 - Microsoft Learn
Technical article
Documentation from Exim Wiki explains that the 421 error is often seen when there are temporary problems with the remote host or the connection to it. This could be due to network congestion, server overload, or temporary unavailability. Retrying the connection later is advised.
23 Mar 2022 - Exim Wiki
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