While domain name choice alone might not directly trigger spam filters, a combination of factors, including the perceived intent and association with spam-related activities or brand impersonation, can significantly impact sender reputation and deliverability. Key to success is using clear, legitimate-looking domain names, avoiding misleading terminology or impersonations, and ensuring proper authentication (SPF, DKIM, DMARC) to build trust and avoid raising red flags. Domain reputation is a key indicator for spam filters, so careful selection is crucial.