What causes Microsoft Office365 MX deferring connections and how is it being resolved?
Matthew Whittaker
Co-founder & CTO, Suped
Published 5 Jun 2025
Updated 17 Aug 2025
8 min read
When I manage email systems, encountering a "451 4.7.500 Server busy. Please try again later" error from Microsoft Office 365 can be a frustrating experience. This message indicates that Office 365's mail exchange (MX) server is temporarily deferring incoming connections, leading to delayed email delivery. It's like calling a busy phone line, where the recipient's server tells your sending server, "I can't take your call right now, please try again later." While these deferrals are typically temporary, they can significantly impact an organization's communication flow and email deliverability, especially when they persist or affect a large volume of messages.
I've observed these deferrals happening across various geographic regions, including North America, Europe, and Australia/New Zealand, suggesting they can sometimes stem from broader, systemic issues within Microsoft's infrastructure rather than isolated incidents. Understanding the root causes and how these issues are addressed is crucial for maintaining a healthy email ecosystem.
What are MX deferrals?
Microsoft Office 365 means that their receiving mail servers are temporarily unable or unwilling to accept an incoming email. The primary reason often communicated is a "server busy" status, often accompanied by specific error codes like 451 4.7.500 (S77714). This isn't necessarily a rejection, but rather a request for the sending server to re-attempt delivery after a certain period. My experience indicates that while a server might indeed be busy, these deferrals frequently point to more complex underlying issues related to traffic management or security protocols.
The MX record, or Mail Exchanger record, is a type of DNS record that specifies a mail server responsible for accepting email messages on behalf of a recipient's domain. When your mail server tries to deliver an email to an Office 365 recipient, it looks up the recipient's MX record to find the correct server. If that server defers the connection, it impacts your ability to deliver emails promptly.
Microsoft, like other major email providers, implements various mechanisms to manage inbound email traffic and protect its users from spam and abuse. This includes throttling, which limits the rate at which emails can be sent from a particular IP address or domain. While throttling is a normal part of email flow management, an unexpected increase in deferrals can signal an issue where normal, legitimate traffic is being unintentionally impacted by these anti-spam measures.
Root causes of Office 365 MX deferrals
Several factors can contribute to Microsoft Office 365 deferring connections. While the immediate message often points to a "server busy" status, the underlying causes are usually more nuanced. I've seen situations where these deferrals are a direct consequence of internal system issues within Microsoft, but they can also be triggered by sender-side factors, particularly related to IP reputation or misconfigurations.
One common cause is a problem with the sender's IP address or domain reputation. If Microsoft's anti-spam filters detect unusual sending patterns, a sudden spike in volume, or perceive the sending IP as low-reputation, they might temporarily defer connections to prevent potential spam. This is a common defense mechanism. For more information on this, you can learn more about Microsoft's temporary rate limiting due to IP reputation.
Another significant factor can be misconfigured mail flow connectors or DNS records. Incorrect MX records, or issues with Microsoft's internal routing, can lead to delivery attempts being misdirected or hitting a server that isn't ready to receive the mail. For instance, the "ATTR35" response code can occur when the MX record or smart host for Microsoft 365 contains an incorrect destination value.
Network issues: Connectivity problems, firewalls blocking connections from Microsoft 365 IP addresses, or general network congestion can also lead to deferrals.
Throttling: Beyond reputation, Microsoft has specific rate limits for SMTP relay. Exceeding these limits, such as sending more than 30 messages per minute through certain relays, can cause messages to be deferred.
These issues can lead to emails getting stuck in queues and significant delays, impacting critical communications.
Microsoft's approach to resolving deferrals
When an incident causes widespread MX deferrals for Microsoft Office 365 users, their response typically involves a multi-stage process. As I've observed, the first step is always identifying the root cause, which can range from unexpected limitations by anti-spam procedures to issues with system throughput or even broken internal scripts. Monitoring the Microsoft 365 Service Health Dashboard is key during these times, as it provides real-time updates.
Initially, Microsoft might attempt to provide immediate relief by manually adding affected IP addresses to an allowed list. This is a quick workaround to mitigate the problem while a more permanent solution is developed. However, as seen in past incidents, initial fixes might not always be successful, requiring further investigation and a new deployment.
The ultimate resolution usually involves a targeted reversion of the code issue or a new fix deployment across the impacted environments. While Microsoft works to resolve these issues, some residual delays can occur as the changes propagate through their vast network. It is important to note that proactive monitoring and transparent communication from Microsoft are essential for organizations relying on their services. For specific cases of email blocking, I often refer to their guidelines on troubleshooting mail delivery issues.
Preventing future MX deferrals
While some deferrals are due to large-scale Microsoft incidents, many can be prevented by maintaining robust email sending practices. My focus is always on ensuring strong sender reputation and proper technical configurations, as these are within your control. This proactive approach significantly reduces the likelihood of your emails being deferred or even blocklisted (or blacklisted).
Maintain sender reputation: Send only to engaged recipients, avoid high bounce rates, and promptly remove invalid or inactive email addresses. High complaint rates or sending to spam traps will quickly degrade your reputation.
Implement email authentication: Properly configure SPF, DKIM, and DMARC records. These authentication protocols verify that your emails are legitimate and prevent spoofing, which helps build trust with receiving servers like Microsoft's. If Microsoft DKIM signatures are failing, this needs immediate attention.
Monitor mail queues and logs: Regularly check your sending server logs for deferral messages or error codes. This early detection allows you to address issues before they escalate into widespread delivery problems. Pay attention to common messages like 451 4.7.500 Server busy.
Adhere to rate limits: Understand and respect the sending limits imposed by major email providers. If you need to send large volumes, consider segmenting your sends or using dedicated IP addresses to avoid hitting these thresholds.
By implementing these measures, you can minimize the chances of your emails encountering deferrals from Office 365 and ensure more consistent deliverability. My advice is always to stay vigilant and adapt your sending strategies as email ecosystems evolve.
Views from the trenches
Best practices
Monitor Microsoft's Service Health Dashboard for real-time updates on widespread issues.
Implement robust email authentication protocols, including SPF, DKIM, and DMARC, to verify legitimacy.
Maintain a clean email list to reduce bounce rates and avoid spam traps, protecting your sender reputation.
Segment large email sends or use dedicated IPs to avoid hitting Microsoft's rate limits and causing deferrals.
Regularly review your mail server logs for deferral messages and specific error codes to detect issues early.
Common pitfalls
Ignoring common deferral messages such as '451 4.7.500 Server busy', assuming they are always transient.
Failing to update or incorrectly configuring MX records and mail flow connectors, leading to misdirected emails.
Sending to unengaged or invalid addresses, which can quickly degrade sender reputation and trigger throttling.
Overlooking network connectivity issues or firewall blocks that prevent proper communication with Microsoft 365 servers.
Not subscribing to Microsoft 365 service notifications, missing critical updates during widespread incidents.
Expert tips
If immediate relief is needed during a widespread incident, inquire if Microsoft is manually allowing affected IP addresses.
When troubleshooting, verify that your sending IP is not on any major blocklists, as this can severely impact delivery.
Utilize Microsoft's own diagnostic tools to analyze connectivity issues and validate mail flow configurations.
Consider leveraging DMARC reports to identify authentication failures that might contribute to deferrals and poor sender reputation.
Proactively test email deliverability to Microsoft domains using various tools to catch potential issues before they impact live campaigns.
Marketer view
Marketer from Email Geeks says they observed Microsoft Office 365 MX deferring connections in US, Canada, Europe, Australia, and New Zealand.
2023-10-11 - Email Geeks
Marketer view
Marketer from Email Geeks says they also noticed it and that there was a Reddit thread discussing the issue.
2023-10-11 - Email Geeks
Conclusion
Microsoft Office 365 MX deferring connections can be a challenging hurdle for anyone managing email delivery. While such issues can sometimes stem from widespread service disruptions on Microsoft's end, a significant portion can be attributed to factors within a sender's control, such as sender reputation and proper email authentication. By actively monitoring service health, diligently configuring SPF, DKIM, and DMARC, and maintaining good sending practices, organizations can minimize the impact of these deferrals. A proactive approach to email deliverability ensures that critical communications reach their intended recipients with minimal delay, upholding the reliability of your email operations.