The Microsoft domain error '452 4.3.1 Insufficient system resources' signifies a temporary issue on the receiving (Microsoft) server, often stemming from overload or resource constraints such as insufficient disk space. This error can also be a result of Microsoft enacting throttling measures, especially for new or unproven IPs, IPs sending too high a volume too quickly, or those exhibiting suspicious sending patterns resembling spam. While documentation confirms its transient nature requiring retries, consistent occurrences can harm sender reputation. Resolving the issue involves adjusting sending practices (slowing down, warming IPs, segmenting), monitoring sending patterns and bounce rates, checking server logs, and potentially engaging with the ESP and recipient's administrator for further investigation. Delays in message delivery can also be associated with this error.
9 marketer opinions
The Microsoft domain error '452 4.3.1 Insufficient system resources' generally indicates a temporary issue, most commonly related to server overload or resource constraints on the receiving (Microsoft) end. This can be triggered by exceeding sending volume limits, especially with new IPs or domains, or by sending patterns resembling spam activity. While typically a transient error requiring automatic retries, persistent occurrences can negatively impact sender reputation, necessitating careful monitoring, adjustments to sending practices (e.g., dialing back connections, warming up IPs, segmenting lists, adjusting sending speed), and communication with the ESP to identify root causes.
Marketer view
Email marketer from Mailjet Blog responds that '452 4.3.1' is a soft bounce, suggesting temporary problems with the recipient's server. It's important to monitor bounce rates and avoid sending to addresses that generate persistent soft bounces.
3 Sep 2024 - Mailjet Blog
Marketer view
Email marketer from Email Deliverability Service shares that Microsoft uses this error code to implement rate limiting, especially if it detects unusual sending patterns or spam-like activity. Adjusting sending speed and segmenting lists can help.
12 Jun 2023 - Email Deliverability Service
3 expert opinions
The Microsoft domain error '452 4.3.1 Insufficient system resources' indicates a temporary issue on the receiving end. Observed delays in email delivery suggest a wider problem possibly affecting multiple platforms. The error often signifies Microsoft employing throttling measures, especially for new or unproven IPs sending high volumes. The root cause can range from a busy server or insufficient disk space to greylisting, necessitating retry attempts for message delivery and careful sending practices to avoid triggering throttling.
Expert view
Expert from Spam Resource responds that the 452 4.3.1 error is often used by Microsoft as a form of throttling. Microsoft can limit the number of connections that an IP can make within a given period and also the message rate. The cause of the throttling might be because your IPs are either new, unproven, or sending too high a message volume too quickly. The recommended action is to slow down your sending speed and try to spread the messages out over a longer period.
22 Apr 2025 - Spam Resource
Expert view
Expert from Email Geeks shares that they are seeing delays of around 15 minutes in some client seed sends and that Mailchimp is also affected.
27 May 2024 - Email Geeks
5 technical articles
The Microsoft domain error '452 4.3.1 Insufficient system resources' signals a temporary issue, generally related to resource constraints or overload on the recipient's server. Official documentation and technical resources uniformly suggest that the sending server should retry delivery after a delay. The error falls under the 4xx category, indicating that the command was accepted but not executed due to a transient problem, and re-requesting the command is appropriate.
Technical article
Documentation from MXToolbox notes that a '452 4.3.1' error may occur if the recipient's mail server is temporarily unable to accept messages due to resource constraints. Retrying delivery after a delay is the recommended approach.
3 Dec 2022 - MXToolbox
Technical article
Documentation from Cisco explains the 4xx status codes in general terms as meaning: The command was accepted, but the requested action did not occur. However, the error is temporary, and the command may be re-requested. For example, this situation can occur if the server is temporarily unable to provide service.
26 Mar 2022 - Cisco
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