When deciding whether to use a new domain or a new from address for software email alerts, several factors related to deliverability and sender reputation come into play. Experts generally recommend using a subdomain or a new 'from' address with the existing domain to avoid the challenges of building a new domain's reputation from scratch. Separating transactional and marketing emails by using different subdomains or dedicated IPs is often suggested to isolate reputation issues. Key considerations include warming up new domains, implementing email authentication protocols (SPF, DKIM, DMARC), and the importance of brand recognition. If possible, using a dedicated MTA or ESP for transactional emails is advisable. Finally, maintaining proper email segmentation and dedicated IP addresses can help manage sending reputation and ensure optimal deliverability.