Troubleshooting Comcast 0% open rates requires a comprehensive approach covering technical configurations, reputation management, policy adherence, and content optimization. Key steps include checking blocklists (Cloudmark, Vade Secure, Spamhaus), verifying SPF, DKIM, and DMARC settings, adhering to Comcast's email policies, warming up IP addresses, monitoring sender reputation using tools like Google Postmaster Tools, maintaining list hygiene, checking bounce messages, using email testing tools, avoiding spam trigger words, monitoring bounce and unsubscribe rates, engaging with Proofpoint if needed, and ensuring compliance with CAN-SPAM. Actively managing sender reputation and optimizing content for deliverability are crucial.