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What are the deliverability risks of using different send-from and reply-to domains or IPs?

Summary

Using different domains or IP addresses for the 'From' (sending) and 'Reply-To' fields in your emails can introduce various deliverability risks. While some senders attempt this to leverage stronger sending reputations or to route replies to a specific inbox, it can confuse mailbox providers (ISPs) and potentially trigger spam filters.

What email marketers say

Email marketers often look for pragmatic solutions to achieve better inbox placement, especially when facing deliverability challenges with a specific domain or IP. The idea of using a 'stronger' sending reputation for the From address while directing replies elsewhere reflects a common desire to optimize immediate delivery.

Marketer view

Email marketer from Email Geeks indicates that they are struggling with deliverability to Gmail for their main domain but are doing well with a subdomain. They are considering sending from the subdomain and setting the reply-to to the main domain to try and get messages into the Gmail inbox.

15 May 2019 - Email Geeks

Marketer view

Marketer from Email Geeks expresses concern about Gmail not recognizing future emails if they switch back to the original 'From' domain after using a different one for sending, highlighting a fear of reputation fragmentation.

15 May 2019 - Email Geeks

What the experts say

Deliverability experts generally advise against practices that can confuse ISPs or dilute sender reputation. While specific implementations might vary, the consensus leans towards consistent sender identity for optimal inbox placement. Using different domains or IPs for the 'From' and 'Reply-To' fields can introduce unnecessary complexity and potential flags.

Expert view

Expert from Email Geeks states that many senders already use different 'From' and 'Reply-To' addresses and it might not be a problem if the email provider supports it. This indicates that while not ideal, it's a practiced configuration.

15 May 2019 - Email Geeks

Expert view

Expert from Email Geeks warns that information about Gmail deliverability from even four months ago might no longer be accurate. This highlights the dynamic nature of ISP filtering and the need to follow up-to-date advice.

15 May 2019 - Email Geeks

What the documentation says

Official documentation and email standards (RFCs) primarily focus on defining how email works and ensuring proper authentication to prevent abuse. While they don't explicitly forbid mismatched 'From' and 'Reply-To' domains, the underlying principles strongly favor consistency to build trust and ensure messages are delivered as intended. Any deviation from standard or expected behavior can be interpreted negatively by compliant mail servers.

Technical article

Klaviyo Help Center documentation clarifies that email deliverability refers to the placement of an email after it is successfully delivered to the recipient's mail server. This definition implies that complex header configurations should not hinder this successful placement, ideally promoting simple, clear sender identities.

22 Mar 2025 - Klaviyo Help Center

Technical article

The RFC 5322 standard for Internet Message Format specifies the 'From' and 'Reply-To' header fields, allowing for distinct addresses. However, it does not detail the deliverability implications when these domains differ, relying on subsequent authentication RFCs.

22 Mar 2025 - RFC 5322

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